BI320 Genetics

for FA 2008

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Mission Statement: The mission of Park University, an entrepreneurial institution of learning, is to provide access to academic excellence, which will prepare learners to think critically, communicate effectively and engage in lifelong learning while serving a global community.

Vision Statement: Park University will be a renowned international leader in providing innovative educational opportunities for learners within the global society.


BI 320 Genetics


FA 2008 HO


Hoffman, Brian L.


Professor of Biology


BA - Chemistry, Biology, Mathematics - Park College (1986)
PhD - Cell and Molecular Biology - Saint Louis University (1996)

Office Location

SC 103

Office Hours

MTRF 10:00-11:30

Daytime Phone



Web Page

Class Days


Class Time

TR 1:00 - 2:15 PM; F 1:50-4:40


BI 231; CH 317 and CH 317L; or permission of instructor

Credit Hours



Genetics: A Conceptual Approach 2/e.  Benjamin Pierce.  WH Freeman

Textbooks can be purchased through the Parkville Bookstore

Additional Resources:

McAfee Memorial Library - Online information, links, electronic databases and the Online catalog. Contact the library for further assistance via email or at 800-270-4347.
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Course Description:
 A study of the principles of heredity and variation in both plants and animals including man. Modern theories of gene action are stressed. Laboratory work is included. PREREQUISITES: BI 231, CH 317 and CH 317L. 3:3:4

Learning Outcomes:
  Core Learning Outcomes

  1. Describe the flow of information in biological organisms in terms of the Central Dogma of Molecular Biology, Mendelian genetics and extensions of Mendelian genetics.
  2. Analyze genetic crosses for inheritance patterns in biological organisms.
  3. Perform basic molecular genetic techniques.
  4. Compare gene expression in prokaryotic and eukaryotic systems.

Core Assessment:
Write a research paper in the style of the journal genesis (formerly Developmental Genetics) covering two of the Drosophila crosses that you will perform in laboratory. This paper should be at least 10 pages in length (using the attached Instructions to Authors) excluding figures and references. Information covered should include:

Background on the mutations that you used.

  1. Description of the general methods that you used for genetic analysis (CLO 2).
  2. Discussion of any Mendelian patterns or non-Mendelian inheritance patterns observed (CLO 1 and CLO 2).
  3. Perform a detailed comparison of mutant and wild-type flies. The chromosomal location of the mutation should be verified using balanced lethal chromosome stocks. Eye color mutations should be analyzed by paper chromatography, eye shape mutations by polymerase chain reaction, and all mutations should be analyzed by cytogenetics to elucidate the nature of the mutation (point mutation, deletion, insertion, inversion, translocation…etc.) (CLO 3).
  4. Discussion of the general flows of the pathway affected by the mutation (flow of information, flow of mass, flow of energy) and the logic underlying the pathway (why does this arrangement work well?) (CLO 1).
  5. Is there a known homolog of this gene that functions in humans? If so, what characteristics/disease states are associated with the gene in humans? If not, predict how the gene MIGHT be involved in human development (CLO 1).
As part of the course, you will be preparing a laboratory notebook. You should photocopy pages of the notebook pertaining to this project and submit them with the paper.

Link to Class Rubric

Class Assessment:

The teaching techniques utilized in this course include: traditional lectures by the instructor, small group discussions, and laboratory application of material learned in lecture. Student preparedness for lecture will be measured through the periodic administration of "pop" quizzes. The student's overall command of genetics will be measured with three regular examinations over lecture material. The examinations will be composed of short answer, matching, solving genetics word problems and short essays.

All course announcements and links to resources will be made using the eCompanion website for the course.


The following weights will be applied to course assignments:

Examinations – 55%
Course Project – 20%
Lab Notebook – 10%
Lab Reports - 5%
Lab Quizzes - 5%
Periodic Quizzes - 5%

The grading scale for this class is:

100-90 = A (4.0 honor points)
89+-80 = B (3.0 honor points)
79+-70 = C (2.0 honor points)
69+-60 = D (1.0 honor point)
Below 60 = F (no honor points)

Late Submission of Course Materials:

Unless announced otherwise, homework is due at the start of the assigned class period. Homework turned in after roll is taken is late. Late homework will be reduced in credit by 25% for each day or part of day that the work is late. Students missing class due to participation in athletic or other school-sponsored events must turn in all homework PRIOR to their absence. Exceptions: students who miss class due to an extended illness requiring hospitalization will be allowed to make up missed homework assignments. Other cases may be considered at the discretion of the instructor.

Classroom Rules of Conduct:

A. Cellular Phones, Beepers, Other Communications Devices

While in class, the class should be your primary focus. Disruption of class due to communications devices has become so prevalent that they are a major distraction in class (to you, to the instructor and to other students). For this reason such devices must not be brought to class or must be inactivated/silenced during class.

B. Student Alcohol or Drug Use

Because the classroom is a professional environment students who are suspected of being under the influence of alcohol or drugs will be removed from class. This also meets our legal obligation to provide a drug- and alcohol-free workplace. Such instances will be reported to the Vice-President for Academic Affairs. Students will not be admitted back into class unless such arrangements are made through the V.P. for Academic Affairs.

C. Student Work, Appointments...Etc.

The student who has signed up for the course has made an obligation to participate in those activities scheduled during regular class times. The student must not make other obligations during this time, or that student alone will be responsible for the consequences. The consequences may include reduced or no credit for that portion of the class and inability to make-up the missed work.

D. Withdrawals

The enrollment status of the student in this course is solely the responsibility of the student. If you wish to change your status in this course, be sure that you file the appropriate paperwork with the registrar before the appropriate deadlines. If you wish to drop, do not just stop coming to class!!! Two weeks of consecutive absences will result in your removal from the class. If you do not file withdrawal papers with the Registrar, you will receive an F in this course.

E. Extra Credit

It is your responsibility to get work done on time in an acceptable form. For this reason, no extra credit will be extended during the course of the semester.

F. Technology Issues

Computers make writing and revising much easier and more productive. Students must recognize though that technology can also cause problems. Printers run out of ink and hard drives crash. Students must be responsible for planning ahead and meeting deadlines in spite of technology. Be sure to save copies of your work to disk, hard drive, and print out paper copies for backup purposes. Papers will be submitted to the drop box in the eCompanion website for this course.

G. Make-Up Examinations

The student will be given the opportunity to make-up one examination during the course of the semester, provided that an adequate excuse is provided to the instructor within 24 hours of the missed examination. The instructor will be the final judge of what constitutes an adequate excuse. The makeup examination will be administered on Friday, December 12 at 8:00 AM and will be a cumulative final.

If you miss two exams, one will be scored as a zero and included in your examination average. Missing three examinations will result in a grade of "F" for the course. Three lecture examinations are scheduled for this semester. Your examination average will be calculated from all four test scores. If you feel that one test score is not representative of your effort, you may opt to take the make-up examination.  Failure to sit for the final examination will result in a grade of "F" for the course.

Athletes involved in sports contests or students participating in other school-sponsored events will be allowed to take the examination prior to the scheduled date. The instructor must be given one week prior notice of such an event.

Course Topic/Dates/Assignments:




August 18

 Setting the Stage: Genetics and Cells
Lab: Mitosis and Mitotic Index

CH 1, 2

August 25

 Mendelian Genetics
Lab: Working with Drosophila, Setting up Monohybrid and Dihybrid Crosses

CH 3

September 1

 Chromosome Theory and Sex Linkage
Lab: Polytene Chromosomes; Karyotypes

CH 4

September 8

 Extensions of Mendelian Genetics
 Lab: Phenocopies; Gene Interaction

CH 5

September 15

 Extensions of Mendelian Genetics

Lab: Corn Genetics and Chi-Square

CH 5

September 22

 Pedigree Analysis
Lab: Pedigrees; Chromatography of Eye Pigments - Drosophila

CH 6

September 29

 Linkage and Recombination
Lab: Linkage in Ascomycete Yeast

CH 7

October 6

Linkage and Recombination
Lab: Humans and Mendelian Genetics

CH 7

October 13

Fall Break

October 20

 Bacterial and Viral Genetic Systems
Lab: Bacteriophage Genetics

CH 8

October 27

 Chromosomal Variation
Lab: Isolation of Plasmid DNA; DNA electrophoresis

CH 9

November 3

Lab: Transfer of Plasmid DNA

CH 10

November 10

 Chromosome Structure
Lab: PCR and  VNTR

CH 11

November 17

Lab: lac Z operon; Isolation of GFP

CH 13

November 24

 Translation and Gene Expression
Lab: Population Genetics simulation and PCR

CH 15/16

November 31

 DNA Mutation and Repair
Lab: Cleanup

CH 17

December 8



September 11 – CH 1-4
October 23 – CH 5-7
November 20 - CH 8-11
December 9 – CH 13-17

Academic Honesty:
Academic integrity is the foundation of the academic community. Because each student has the primary responsibility for being academically honest, students are advised to read and understand all sections of this policy relating to standards of conduct and academic life.   Park University 2008-2009 Undergraduate Catalog Page 87

Plagiarism involves the use of quotations without quotation marks, the use of quotations without indication of the source, the use of another's idea without acknowledging the source, the submission of a paper, laboratory report, project, or class assignment (any portion of such) prepared by another person, or incorrect paraphrasing. Park University 2008-2009 Undergraduate Catalog Page 87

Attendance Policy:
Instructors are required to maintain attendance records and to report absences via the online attendance reporting system.

  1. The instructor may excuse absences for valid reasons, but missed work must be made up within the semester/term of enrollment.
  2. Work missed through unexcused absences must also be made up within the semester/term of enrollment, but unexcused absences may carry further penalties.
  3. In the event of two consecutive weeks of unexcused absences in a semester/term of enrollment, the student will be administratively withdrawn, resulting in a grade of "F".
  4. A "Contract for Incomplete" will not be issued to a student who has unexcused or excessive absences recorded for a course.
  5. Students receiving Military Tuition Assistance or Veterans Administration educational benefits must not exceed three unexcused absences in the semester/term of enrollment. Excessive absences will be reported to the appropriate agency and may result in a monetary penalty to the student.
  6. Report of a "F" grade (attendance or academic) resulting from excessive absence for those students who are receiving financial assistance from agencies not mentioned in item 5 above will be reported to the appropriate agency.

Park University 2008-2009 Undergraduate Catalog Page 89-90
Attendance at all class meetings is mandatory. Part of the education of college is preparation for professional conduct. Attendance at work or graduate or professional school is mandatory for remaining employed or in school. Get in the habit of being here all of the time now. Education is also a cooperative effort. You are as responsible for furthering the education of your fellow classmates and the instructor as the instructor is for yours.

It is recognized that personal emergencies will arise during the course of the semester. Three absences (for any reason: illness, personal appointments, doctors appointments car problems...etc.) are allowed without penalty. After 3 absences, 5% will be deducted from the students grade for each subsequent absence. Eight absences is considered excessive, and the student missing eight classes will fail the course. Students who miss class will be responsible for the assignments made and material covered in that class period. Students who enter class after roll is taken will be counted tardy. Two tardies count as an absence. Students who are 15 minutes late (by my watch) will be counted absent.

Exceptions: Athletes who miss class for an athletic contest or students who miss class due to other school sponsored events will not be penalized IF AND ONLY IF THE INSTRUCTOR IS GIVEN TWO LECTURE MEETINGS PRIOR NOTICE AND WORK IS TURNED IN AND EXAMS TAKEN BEFORE THE CLASS IS MISSED!!!!!!!!!! If you have an illness that requires extended hospitalization, have someone contact me!

Disability Guidelines:
Park University is committed to meeting the needs of all students that meet the criteria for special assistance. These guidelines are designed to supply directions to students concerning the information necessary to accomplish this goal. It is Park University's policy to comply fully with federal and state law, including Section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Act of 1990, regarding students with disabilities. In the case of any inconsistency between these guidelines and federal and/or state law, the provisions of the law will apply. Additional information concerning Park University's policies and procedures related to disability can be found on the Park University web page: .

Genetics Term Project


CompetencyExceeds Expectation (3)Meets Expectation (2)Does Not Meet Expectation (1)No Evidence (0)
Uses 7 or more sources Uses 4 to 6 sources Uses 3 to 5 sources Uses fewer than 3 sources 
Identifies and analyzes 6 of the items in the assignment Identifies and analyzes 4 to 5 of the items in the assignment Identifies and analyzes 2 to 3 of the items in the assignment Identifies and analyzes fewer than 2 of the items in the assignment 
Assesses the outcomes of 6 of the assignment items Assesses the outcomes of 4 to 5 of the assignment items Assesses the outcomes of 2 to 3 of the assignment items Assesses the outcomes of  fewer than 2 of the assignment items 
No factual errors 1 to 2 factual errors 3 to 4 factual errors 5 or more factual errors 
Demonstrates mastery of 6 of the assignment items Demonstrates mastery of 4 to 5 of the assignment items Demonstrates mastery of 2 to 3 of the assignment items Demonstrates mastery of fewer than 2 of the assignment items 
Effectively incorporates 7 or more sources to support thesis Effectively incorporates 4 to 6 sources to support thesis Effectively incorporates 3 to 5 sources to support thesis Effectively incorporates fewer than 3 sources to support thesis 
Whole Artifact                                                                                                                                                                                                                                             
No errors in writing conventions 1 to 3 errors in writing conventions 4 to 6 errors in writing conventions 7 or more errors in writing conventions 
Contains no errors in the following paper format items: -genesis format –Length -Page numbers -Works cited -Internal documentation Contains only 1 error in the following paper format items: -genesis format –Length -Page numbers -Works cited -Internal documentation

Contains 2 to 3 errors in the following paper format items: -genesis format –Length -Page numbers -Works cited--Internal documentation Contains 4 or more errors in the following paper format items: -genesis format –Length -Page numbers -Works cited -Internal documentation

Exhibits an awareness and concern for contemporary items Exhibits an awareness or concern for contemporary items Exhibits some awareness and concern for contemporary items Exhibits no awareness or concern for contemporary items 


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Last Updated:7/30/2008 1:37:15 PM