Mission Statement: The mission of Park University, an entrepreneurial institution of learning, is to provide access to academic excellence, which will prepare learners to think critically, communicate effectively and engage in lifelong learning while serving a global community.Vision Statement: Park University will be a renowned international leader in providing innovative educational opportunities for learners within the global society.CourseBI 337 BiochemistrySemesterFA 2009 HOFacultyBurns, Douglas M.Title-- Associate Professor of BiologyDegrees/Certificates-- B.A. (Honors) in Biological Sciences, University of Missouri -Columbia-- Ph.D. in Molecular Biology, Vanderbilt University-- Postdoctoral Training in Biochemistry, CWRU School of MedicineOffice Location113A, Science HallOffice Hours2-4pm, M; 12-1 pm, T. 12-2pm R; and 1-3:00, FDaytime Phone584-6592E-Maildburns@park.eduSemester Dates17 August -- 11 December, 2009Class Days-M-W-F-Class Time10:00 - 10:50 AMPrerequisitesCH318 and CH318L and/or the equivalentCredit Hours3Textbook:
Biochemistry: A Short Course by Tymoczko, Berg, & Stryer, 1st edition, 2010, WH Freeman & Co. New York, NY (ISBN-13: 978-0-7167-5840-2).
This textbook will provide the basis for almost all the material covered in class.
BI 337 Biochemistry
FA 2009 HO
Burns, Douglas M.
-- Associate Professor of Biology
-- B.A. (Honors) in Biological Sciences, University of Missouri -Columbia-- Ph.D. in Molecular Biology, Vanderbilt University-- Postdoctoral Training in Biochemistry, CWRU School of Medicine
113A, Science Hall
2-4pm, M; 12-1 pm, T. 12-2pm R; and 1-3:00, F
17 August -- 11 December, 2009
10:00 - 10:50 AM
CH318 and CH318L and/or the equivalent
Textbooks can be purchased through the MBS bookstore
Textbooks can be purchased through the Parkville Bookstore
McAfee Memorial Library - Online information, links, electronic databases and the Online catalog. Contact the library for further assistance via email or at 800-270-4347.Career Counseling - The Career Development Center (CDC) provides services for all stages of career development. The mission of the CDC is to provide the career planning tools to ensure a lifetime of career success.Park Helpdesk - If you have forgotten your OPEN ID or Password, or need assistance with your PirateMail account, please email email@example.com or call 800-927-3024Resources for Current Students - A great place to look for all kinds of information http://www.park.edu/Current/.
Learning Outcomes: Core Learning Outcomes
Create a review paper in the style of Annual Reviews in Biochemistry covering one biochemical or intercellular signaling pathway in a cell or cells. This paper should be at least 10 pages in length (using the attached Instructions to Authors) excluding figures and references. Information covered should include:
1. Step-by-step illustration of the biochemical or intercellular signaling pathway (CLO 1, 2).
2. Discussion of the general flows of the pathway (flow of information, flow of mass, flow of energy) and the logic underlying the pathway (why does this arrangement work well?) (CLO 1,2, 3).
3. Indication of key regulatory steps in the pathway and explanation of why this is a logical regulatory step (CLO 1, 2, 4).
4. Indication of how this pathway relates to the central metabolic pathway (glycolysis, TCA cycle, electron transport chain, oxidative phosphorylation) (CLO 2).
5. Discuss the commonalities and differences exhibited in this pathway in prokaryotes and eukaryotes (CLO 4).
6. What diseases or disease states are associated with defects in this pathway? If there is no literature, predict what would happen (indicate your rationale) (CLO 1, 2, 4).
7. Discuss how the disease states in 6 are differentially expressed in human populations (is there a difference in disease effect or prevalence based on age, sex, geographic location, environmental factors, ancestral origin, race…etc). What are the bases of these differences? If there appears to be no difference in disease effect or prevalence, discuss why.
8. Discuss methods used to combat the disease or approaches that are planned. How do/will these work?
Link to Class RubricClass Assessment:
Late Submission of Course Materials:
Classroom Rules of Conduct:
TENTATIVE SCHEDULE FOR BI337/CH337 FALL OF 2009
3-meetings + 1 lab/week
Topic/Topics for the indicated week
1. Week of 8/17
Intro – Special Biological Conditions in a Cell
– “Bio-chemistry” and Bio-organic Chemistry
1 & 2
2. Week of 8/24
Carbohydrates -- Lipids -- Amino Acids
9, 10, & 3
3. Week of 8/31
Proteins – 3D Configurations – Enzymes & Enzymatic Action – “Gene Flow” in a Cell – Cell Membranes
4, 5, & notes
4. Week of 9/07
Summation, Exam-I; Enzyme Kinetics & Regulation– Enzyme Mechanisms & Inhibitors
-- 6, 7
5. Week of 9/14
Enzyme Mechanisms & Inhibitors – Allosteric Proteins
6. Week of 9/21
Membrane Function – Cell Regulation/“Signal Transduction” -- Biochemical Nutrients from Digestion
7. Week of 9/28
Exam-II; Metabolism -- “Glycolysis”
-- 14, 15
8. Week of 10/05
Linking Glycolysis to Cell Respiration
9. Week of 10/12
FALL RECESS; GET SOME REST; TIME OFF !!
10. Week of 10/19
Citric Acid Cycle -- The Electron-Transport Chain
and “Oxidative Phosphorylation”
11. Week of 10/26
Exam-III; Glycogen Degradation and Synthesis
12. Week of 11/02
The Pentose Phosphate Shunt
-- Lipid Synthesis & Degradation
13. Week of 11/09
Lipid Synthesis & Storage; Cholesterol synthesis -- Veteran’s Day -- Exam-IV;
14. Week of 11/16
Nucleotide Metabolism – DNA & RNA structure
– DNA Replication
30, 32, 33
15. Week of 11/23
RNA Synthesis in Prokaryotes & Eukaryotes – And Its Regulation ! -- Thanksgiving Break (11/26 -29)
16. Week of 11/30
Eukaryotic Gene Expression – The Genetic Code –
The Biosynthesis of Proteins (Translation)
36, 38, 39
ALL TERM PAPERS MUST BE RECEIVED
BEFORE 12/01 !!
! ! ! ! ! !
12/7 – 12/10
Exam-Vwill be at time scheduled for the FINAL
Academic Honesty:Academic integrity is the foundation of the academic community. Because each student has the primary responsibility for being academically honest, students are advised to read and understand all sections of this policy relating to standards of conduct and academic life. Park University 2008-2009 Undergraduate Catalog Page 87 Please do not share or copy answers for any assignment, including lab write-ups, exam answers, and lab projects. Students should never copy verbatim from books, manuals, or internet sources (see below). Do not copy from someone else's exam paper or whisper answers to each other during exams. (Both students will receive a 0 for that exam.)
Plagiarism:Plagiarism involves the use of quotations without quotation marks, the use of quotations without indication of the source, the use of another's idea without acknowledging the source, the submission of a paper, laboratory report, project, or class assignment (any portion of such) prepared by another person, or incorrect paraphrasing. Park University 2009-2010 Undergraduate Catalog Page 92PLEASE be careful not to plagiarize; we have several programs that will easily detect such behavior within the patterns of your written work.
Attendance Policy:Instructors are required to maintain attendance records and to report absences via the online attendance reporting system.
Park University 2009-2010 Undergraduate Catalog Page 95It is MANDATORY that you attend all class meetings and all scheduled laboratories. Part of a university education is preparation for professional conduct in your future life. Attendance at work or graduate/professional school is mandatory -- if you wish to remain employed or enrolled.
In addition, education is a cooperative effort, and you are as responsible for furthering the education of your fellow classmates and the instructor as the instructor is for educating you. Get in the habit of being here on time, for this is a behavior you will need to cultivate if you wish to succeed.
Be advised that a student is always responsible for any class material, whether they are present during a particular class session -- or not. It is the responsibility of the student to obtain notes and any notice of assignments due or announcements made on their own.
There are NO EXCUSED ABSENCES in this course for any reason (medical, personal, job-related, mechanical failure, death in the family, death of a beloved pet, death of ambition, and so forth). However, since personal emergencies may nonetheless occur during the semester, your first four (4) absences (lecture and/or lab) are free and will draw you no penalty.
HOWEVER, with each additional absence past the first four, 5% will be deducted from the student's final overall grade for the course. Furthermore, eight (8) absences in a twice-a-week semester class is an excessive number, and you will automatically be given an F after you miss eight (8) lecture or lab sessions (for ANY reason).
TARDINESS or LEAVING: Quizzes are typically given within the first 10 minutes or the last 10 minutes of class. If you miss them, these can never be made up. Some quizzes are “bonus” – meaning that you can actually gain extra points by knowing something; other quizzes are evaluative – meaning that you will lose points if you don't know all the answers.
EXCEPTION FOR SCHOOL ACTIVITIES: Athletes who miss class for an athletic event or contest or students who miss class due to other school sponsored events will not be penalized IF AND ONLY IF the instructor is GIVEN WRITTEN NOTICE ONE WEEK IN ADVANCE -- and -- BOTH WORK ASSIGNMENTS AND EXAMS ARE TAKEN BEFORE ACTUAL ABSENCE!
Disability Guidelines:Park University is committed to meeting the needs of all students that meet the criteria for special assistance. These guidelines are designed to supply directions to students concerning the information necessary to accomplish this goal. It is Park University's policy to comply fully with federal and state law, including Section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Act of 1990, regarding students with disabilities. In the case of any inconsistency between these guidelines and federal and/or state law, the provisions of the law will apply. Additional information concerning Park University's policies and procedures related to disability can be found on the Park University web page: http://www.park.edu/disability .Although you have the right to keep all conditions private, my desire is to help anyone who has any sort of trouble taking the class. If you come and talk with me about known problems, we can make certain that you are getting the help you deserve.
Last Updated:8/13/2009 6:17:49 PM